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Chemical Structure : ISCA2 inhibitor 25
Catalog No.: PC-49374Not For Human Use, Lab Use Only.
ISCA2 inhibitor 25 is a selective, orally available small molecule inhibitor of HIF-2α with IC50 of 0.92 uM, decrease HIF-1/2α levels and induce ferroptosis by targeting Iron Sulfur Cluster Assembly 2 (ISCA2), a component of the late mitochondrial Iron Sulfur Cluster (L-ISC) assembly complex.
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ISCA2 inhibitor 25 is a selective, orally available small molecule inhibitor of HIF-2α with IC50 of 0.92 uM, decrease HIF-1/2α levels and induce ferroptosis by targeting Iron Sulfur Cluster Assembly 2 (ISCA2), a component of the late mitochondrial Iron Sulfur Cluster (L-ISC) assembly complex.
ISCA2 inhibitor 25 decreases HIF-2α protein levels by blocking iron-responsive element (IRE)-dependent translation, and at higher concentrations, also decreases HIF-1α translation through unknown mechanisms.
ISCA2 inhibitor 25 triggers the iron starvation response, resulting in iron/metals overload and death via ferroptosis.
ISCA2 inhibitor 25 (60 mg/kg) significantly reduced ccRCC xenograft growth in vivo, decreased HIF-α levels and increased lipid peroxidation, suggesting increased ferroptosis in vivo.
| M.Wt | 368.353 | |
| Formula | C17H16N6O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Green YS, et al. Oncogene. 2022 Sep 12. doi: 10.1038/s41388-022-02460-1.
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