Catalog No.: PC-23633Not For Human Use, Lab Use Only.
Garutadustat (ISM012-042) is a potent, orally gut-restricted, selective PHD1 and PHD2 inhibitor with IC50 of 1.9 nM and 2.5 nM for PHD1 hydroxylase and PHD2 hydroxylase, respectively.
Garutadustat (ISM012-042) is a potent, orally gut-restricted, selective PHD1 and PHD2 inhibitor with IC50 of 1.9 nM and 2.5 nM for PHD1 hydroxylase and PHD2 hydroxylase, respectively.
ISM012-042 exhibits gut-restricted pharmacokinetic (PK) properties, excellent activity and specificity against PHDs.
ISM012-042 resolves colitis, restores intestinal barrier function and reprograms the colonic immune environment.
ISM012-042 inhibited PHDs independently of extracellular iron levels and exerted anticolitis activity at markedly lower doses than SOC treatment mesalamine.
ISM012-042 attenuated colitis by restoring intestinal barrier function and alleviating intestinal inflammation.
