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Chemical Structure : IT1t
Catalog No.: PC-42390Not For Human Use, Lab Use Only.
A highly potent, selective, orally bioavailable CXCR4 inhibitor with binding IC50 of 8 nM for hCXCR4, IC50 of 1.1 nM in Ca2+-mobilization assays.
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IT1t (Isothiourea 1t) is a highly potent, selective, orally bioavailable CXCR4 inhibitor with binding IC50 of 8 nM for hCXCR4, IC50 of 1.1 nM in Ca2+-mobilization assays.
IT1t inhibits HIV-1IIIB attachment with IC50 of 7 nM, and IC90 of 100 nM.
IT1t also show promising anti-tumor effects, impairs the formation of TNBC early metastases in a zebrafish xenograft model.
| M.Wt | 406.65146 | |
| Formula | C21H34N4S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO |
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1. Wu B, et al. Science. 2010 Nov 19;330(6007):1066-71.
2. Thoma G, et al. J Med Chem. 2008 Dec 25;51(24):7915-20.
3. Das D, et al. Antimicrob Agents Chemother. 2015 Apr;59(4):1895-904.
4. Tulotta C, et al. Dis Model Mech. 2016 Feb;9(2):141-53.
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