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Chemical Structure : ITD-1
CAS No.: 1099644-42-4
Catalog No.: PC-43159Not For Human Use, Lab Use Only.
ITD-1 is a potent, selective TGF-β inhibitor that induces type II TGFβ receptor (TGFBR2) degradation with IC50 of 0.85 uM, enhances proteasomal degradation of TGFBR2.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $98 | In stock | |
| 25 mg | $288 | In stock | |
| 100 mg | $588 | In stock | |
| 500 mg | Get quote |
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ITD-1 is a potent, selective TGF-β inhibitor that induces type II TGFβ receptor (TGFBR2) degradation with IC50 of 0.85 uM, enhances proteasomal degradation of TGFBR2; effectively clears the receptor from the cell surface and selectively inhibits intracellular signaling; selectively enhances the differentiation of uncommitted mesoderm to cardiomyocytes, but not to vascular smooth muscle and endothelial cells.
| M.Wt | 415.524 | |
| Formula | C27H29NO3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: < 9 mg/mL |
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| Chemical Name/SMILES |
3-Quinolinecarboxylic acid, 4-[1,1'-biphenyl]-4-yl-1,4,5,6,7,8-hexahydro-2,7,7-trimethyl-5-oxo-, ethyl ester |
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1. Willems E, et al. Cell Stem Cell. 2012 Aug 3;11(2):242-52.
2. Sun Z, et al. Dev Biol. 2017 Jan 15;421(2):149-160.
3. Mingyuan X, et al. Oncotarget. 2017 Dec 14;9(3):3188-3197.
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