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Chemical Structure : ITRI-E-(S)4046
Catalog No.: PC-21300Not For Human Use, Lab Use Only.
ITRI-E-(S)4046 (E(S)4046) is a potent, highly specific, dual synergistic inhibitor of myosin light chain kinase 4 (MYLK4) and Rho-related protein kinase (ROCK) with IC50 of 3.2 nM and 25.6 nM for ROCK1 and MYLK4, respectively.
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ITRI-E-(S)4046 (E(S)4046) is a potent, highly specific, dual synergistic inhibitor of myosin light chain kinase 4 (MYLK4) and Rho-related protein kinase (ROCK) with IC50 of 3.2 nM and 25.6 nM for ROCK1 and MYLK4, respectively.
ITRI-E-(S)4046 potently inhibits myosin light chain (MLC) phosphorylation (pMLC) with IC50 of 50.4 nM in HTM cells.
ITRI-E-(S)4046 exhibits a selective kinase inhibition profile targeting on the AGC kinase subfamily, and MYLK4, shows high specificity against protein kinase A, G, and C families.
ITRI-E-(S)4046 can reduceintraocular pressure (IOP) in normotensive and hypertensive animal models.
| M.Wt | 306.37 | |
| Formula | C18H18N4O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Yi-Hsun Chen, et al. Invest Ophthalmol Vis Sci. 2021 Oct 4;62(13):12.
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