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Chemical Structure : ITZ-1
Catalog No.: PC-63360Not For Human Use, Lab Use Only.
ITZ-1 is a client-selective Hsp90 inhibitor that efficiently induces heat shock factor 1 (HSF1) activation, selectively inhibits IL-1β-induced MMP-13 production (IC50=0.51 uM) via inhibition of ERK activation.
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ITZ-1 is a client-selective Hsp90 inhibitor that efficiently induces heat shock factor 1 (HSF1) activation, selectively inhibits IL-1β-induced MMP-13 production (IC50=0.51 uM) via inhibition of ERK activation.
ITZ-1 causes mild Raf-1 degradation, but scarcely induces degradation of a broad range of Hsp90 client proteins by binding to the Hsp90 C terminus.
ITZ-1 suppresses both IL-1β-induced proteoglycan and collagen release from bovine nasal cartilage in vitro and suppresses intra-articular infusion of IL-1β-induced cartilage proteoglycan degradation in rat knee joints.
| M.Wt | 541.57 | |
| Formula | C20H20F5N3O3S3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Kimura H, et al. Chem Biol. 2010 Jan 29;17(1):18-27.
2. Kimura H, et al. J Pharmacol Sci. 2009 Jun;110(2):201-11.
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