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Chemical Structure : IW-927
Catalog No.: PC-70230Not For Human Use, Lab Use Only.
IW-927 is a potent TNFα/TNFRc1 interaction antagonist with IC50 of 50 nM, with no affinity for the related cytokine receptors TNFRc2 or CD40, and no cytotoxicity (>100 uM).
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IW-927 is a potent TNFα/TNFRc1 interaction antagonist with IC50 of 50 nM, with no affinity for the related cytokine receptors TNFRc2 or CD40, and no cytotoxicity (>100 uM).
IW-927 also blocks TNF-stimulated phosphorylation of Ikappa-B in Ramos cells (IC50=600 nM)
| M.Wt | 441.564 | |
| Formula | C22H23N3O3S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Carter PH, et al. Proc Natl Acad Sci U S A. 2001 Oct 9;98(21):11879-84.
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