Chemical Structure : IWP-3
CAS No.: 687561-60-0
Catalog No.: PC-25594Not For Human Use, Lab Use Only.
IWP-3 is a potent, small molecule inhibitor of Wnt production with IC50 of 40 nM, inhibits Porcupine (Porcn) function thereby blocking palmitoylation of Wnt proteins, inhibits CK1γ3 and CK1ε, does not inhibit CK1α.
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IWP-3 is a potent, small molecule inhibitor of Wnt production with IC50 of 40 nM, inhibits Porcupine (Porcn) function thereby blocking palmitoylation of Wnt proteins, inhibits CK1γ3 and CK1ε, does not inhibit CK1α.
| M.Wt | 484.58 | |
| Formula | C22H17FN4O2S3 | |
| Appearance | Solid | |
| Storage | 
                            
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| Solubility | 
                             10 mM in DMSO  | 
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| Chemical Name/SMILES | 
                             2-((3-(4-Fluorophenyl)-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(6-methylbenzo[d]thiazol-2-yl)acetamide  | 
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1. Baozhi Chen, et al. Nat Chem Biol. 2009 Feb;5(2):100-7.

                
                
                
                
                
                
                
                
            
            
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