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Chemical Structure : IWR-1
CAS No.: 1127442-82-3
Catalog No.: PC-42926Not For Human Use, Lab Use Only.
IWR-1 is a potent inhibitor of Wnt signaling with EC50 of 0.2 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $68 | In stock | |
| 25 mg | $108 | In stock | |
| 50 mg | $178 | In stock | |
| 100 mg | Get quote |
Bulk size, bulk discount!
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IWR-1 is a potent inhibitor of Wnt signaling with EC50 of 0.2 uM.
IWR-1 induces Axin2 protein levels and promotes β-catenin phosphorylation by stabilizing Axin-scaffolded destruction complexes.
IWR-1 inhibites the promoting effect of MIF on NSPC differentiation to neuron lineage, partially reverses the FSH-induced inhibition of granulosa cell CARTPT mRNA expression.
| M.Wt | 409.4366 | |
| Formula | C25H19N3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 46 mg/mL |
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| Chemical Name/SMILES |
Benzamide, 4-[(3aR,4S,7R,7aS)-1,3,3a,4,7,7a-hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl]-N-8-quinolinyl-, rel- |
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1. Lu J, et al. Bioorg Med Chem Lett. 2009 Jul 15;19(14):3825-7.
2. Narwal M, et al. J Med Chem. 2012 Feb 9;55(3):1360-7.
3. Kulak O, et al. Mol Cell Biol. 2015 Jul;35(14):2425-35.
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