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IZCZ-3

Chemical Structure : IZCZ-3

CAS No.: 2223019-53-0

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IZCZ-3 (IZCZ3)

Catalog No.: PC-27086Not For Human Use, Lab Use Only.

IZCZ-3 is a potent, small molecule inhibitor of c-MYC transcription inhibitor, binds and stabilizes the c-MYC G-quadruplex.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

IZCZ-3 is a potent, small molecule inhibitor of c-MYC transcription inhibitor, binds and stabilizes the c-MYC G-quadruplex.
IZCZ-3 provokes cell cycle arrest and apoptosis and inhibits cell growth, primarily by blocking c-MYC transcription through specific targeting of the promoter G-quadruplex structure.
IZCZ-3 effectively suppressed tumor growth in a mouse xenograft model.

Physicochemical Properties

M.Wt 715.95
Formula C46H49N7O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

9-Ethyl-3-(1-(4-methoxyphenyl)-4,5-bis(4-(4-methylpiperazin-1-yl)phenyl)-1H-imidazol-2-yl)-9H-carbazole

References

1. Hu MH, et al. J Med Chem. 2018 Mar 22;61(6):2447-2459.

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