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Chemical Structure : Ibodutant
Catalog No.: PC-70191Not For Human Use, Lab Use Only.
A potent and selective linear tachykinin NK2 receptor antagonist with pKb of 9.3.
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A potent and selective linear tachykinin NK2 receptor antagonist with pKb of 9.3; displays >1,000-fold selectivity over NK1 and NK3 (pKb<6); induces a concentration-dependent rightward shift of the [βAla(8)]NKA(4-10) concentration-response curves without depressing the maximal contractile effect (3-100 nM); shows good in vivo activity after intravenous, intraduodenal, and oral administration in guinea pigs.
Irritable Bowel Syndrome
Phase 3 Clinical
| M.Wt | 644.866 | |
| Formula | C37H48N4O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Meini S, et al. J Pharmacol Exp Ther. 2009 May;329(2):486-95.
2. Fedi V, et al. J Med Chem. 2007 Oct 4;50(20):4793-807.
3. Santicioli P, et al. Eur J Pharmacol. 2013 Feb 28;702(1-3):32-7.
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