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Chemical Structure : Ibulocydine
Catalog No.: PC-62682Not For Human Use, Lab Use Only.
Ibulocydine is the prodrug of CDK inhibitor BMK-Y101, inhibits CDK7 and CDK9 with IC50 of 530 nM and 85 nM in kinase assays, respectively.
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Ibulocydine is the prodrug of CDK inhibitor BMK-Y101, inhibits CDK7 and CDK9 with IC50 of 530 nM and 85 nM in kinase assays, respectively.
Ibulocydine reduces the phosphorylation of RNA polymerase II at Ser-5 and Ser-2, down-regulates Mcl-1, survivin, and XIAP and induces apoptosis.
Ibulocydine shows effectivity in HCC xenografts with no toxic side effects.
| M.Wt | 458.269 | |
| Formula | C16H20BrN5O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Cho SJ, et al. J Biol Chem. 2011 Jun 3;286(22):19662-71.
2. Park SS, et al. Radiother Oncol. 2014 Aug;112(2):295-301.
3. Park SS,, et al. Int J Biochem Cell Biol. 2017 Feb;83:47-55.
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