Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : Icilin
CAS No.: 36945-98-9
Catalog No.: PC-42799Not For Human Use, Lab Use Only.
Icilin (AG-3-5) is asuper-cooling agent that fuctions as a potent TRPM8 agonist with EC50 of 0.2 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg (Free Sample) | $18 | In stock | |
| 10 mg | $78 | In stock | |
| 25 mg | $128 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Icilin (AG-3-5) is asuper-cooling agent that fuctions as a potent TRPM8 agonist with EC50 of 0.2 uM.
Icilin (AG-3-5) also activate other cold-transducing receptors such as ANKTM1, increased [Ca2+]i in mTRPM8-transfected HEK293 cells, this effect can be inhibited by low pH.
| M.Wt | 311.2921 | |
| Formula | C16H13N3O4 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
DMSO: ≥ 54 mg/mL |
|
| Chemical Name/SMILES |
2(1H)-Pyrimidinone, 3,6-dihydro-1-(2-hydroxyphenyl)-4-(3-nitrophenyl)- |
|
1. Andersson DA, et al. J Neurosci. 2004 Jun 9;24(23):5364-9.
2. Behrendt HJ, et al. Br J Pharmacol. 2004 Feb;141(4):737-45.
3. McKemy DD, Nature. 2002 Mar 7;416(6876):52-8.et al.
4. Chuang HH, et al. Neuron. 2004 Sep 16;43(6):859-69.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
