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Chemical Structure : Ifetroban sodium
Catalog No.: PC-20715Not For Human Use, Lab Use Only.
Ifetroban sodium (BMS-180291, CPI211) is a potent and highly selective antagonist of thromboxane A2/prostaglandin endoperoxide (TP) receptors, inhibits platelet aggregation induced by arachidonate (800 uM) and U-46,619 (10 uM) with IC50 of 7 and 21 nM, respectively.
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Ifetroban sodium (BMS-180291, CPI211) is a potent and highly selective antagonist of thromboxane A2/prostaglandin endoperoxide (TP) receptors, inhibits platelet aggregation induced by arachidonate (800 uM) and U-46,619 (10 uM) with IC50 of 7 and 21 nM, respectively.
BMS 180,291 antagonized U-46,619-induced platelet shape change competitively with a KB of 11 nM.
BMS 180,291 did not inhibit platelet aggregation induced by high concentrations of ADP (20 microM) or human alpha-thrombin (1 U/ml) at 1 uM. BMS 180,291 antagonized U-46,619-induced concentrations of rat aortae with a KB of 0.6 nM.
Ifetroban sodium (BMS-180291, CPI211) potently blocked spontaneous metastasis from primary tumors, without affecting tumor cell proliferation, motility, or tumor growth.
| M.Wt | 462.52 | |
| Formula | C25H31N2NaO5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. M L Ogletree, et al. J Pharmacol Exp Ther. 1993 Feb;264(2):570-8.
2. Werfel TA, et al. 2020 Dec;19(12):2454-2464.
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