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Chemical Structure : Iguratimod
CAS No.: 123663-49-0
Catalog No.: PC-45134Not For Human Use, Lab Use Only.
Iguratimod (TT-614) is an antirheumatic agent that acts as an inhibitor of COX-2 with IC50 of 20 μM, does not inhibit COX-1, also inhibits macrophage migration inhibitory factor (MIF) with IC50 of 6.81 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $88 | In stock | |
| 10 mg | $128 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | $358 | In stock | |
| 100 mg | Get quote |
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Iguratimod (TT-614) is an antirheumatic agent that acts as an inhibitor of COX-2 with IC50 of 20 μM, does not inhibit COX-1, also inhibits macrophage migration inhibitory factor (MIF) with IC50 of 6.81 uM.
Iguratimod (TT-614) is a disease-modifying antirheumatic drug that inhibits NF-kappaB (NF-κB) p65 subunit (RelA) phosphorylation and nuclear translocation without affecting IKBα degradation.
Iguratimod (TT-614) inhibits LPS-stimulated production of TNF-α, IL-6, and IL-8 with decreasing mRNA levels (IL-6 and IL-8).
Iguratimod (TT-614) mainly targets Act1 to disrupt the interaction between Act1 and TRAF5 and IKKi in the IL-17 pathway of synoviocytes.
Iguratimod (TT-614) also exhibts selective MIF inhibition in vitro and in vivo.
| M.Wt | 374.3679 | |
| Formula | C17H14N2O6S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Methanesulfonamide, N-[3-(formylamino)-4-oxo-6-phenoxy-4H-1-benzopyran-7-yl]- |
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1. Luo Q, et al. J Immunol. 2013 Nov 15;191(10):4969-78.
2. Bloom J, et al. J Biol Chem. 2016 Dec 16;291(51):26502-26514.
3. Aikawa Y, et al. Inflamm Res. 2002 Apr;51(4):188-94.
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