Imetelstat (GRN163L)

Chemical Structure : Imetelstat

CAS No.: 868169-64-6

Catalog No.: PC-22757Not For Human Use, Lab Use Only.

Imetelstat (GRN163L) is a first-in-class, lipid-conjugated N3'→P5' thio-phosphoramidate oligonucleotide telomerase inhibitor with IC50 of 0.45 uM, blocks the template region of telomerase.

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0.5 mg	$548	In stock
1 mg	$898	In stock
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Biological Activity

Imetelstat (GRN163L) is a first-in-class, lipid-conjugated N3'→P5' thio-phosphoramidate oligonucleotide telomerase inhibitor with IC50 of 0.45 uM, blocks the template region of telomerase.

Physicochemical Properties

M.Wt	4610.18
Formula	C148H211N68O53P13S13
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[3-[[(2S,3S,5R)-3-[[[(2S,3S,5R)-3-[[[(2S,3S,5R)-3-[[[(2S,3S,5R)-3-[[[(2S,3S,5R)-3-[[[(2S,3S,5R)-3-[[[(2S,3S,5R)-3-[[[(2S,3S,5R)-3-[[[(2S,3S,5R)-3-[[[(2S,3S,5R)-3-[[[(2S,3S,5R)-3-[[[(2S,3S,5R)-3-[[[(2S,3S,5R)-3-amino-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphinothioyl]amino]-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphinothioyl]amino]-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphinothioyl]amino]-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphinoth

References

1. Marian CO, et al. Clin Cancer Res. 2010 Jan 1;16(1):154-63.

2. Burchett KM, et al. PLoS One. 2014 Jan 7;9(1):e85155.