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Chemical Structure : InS3-54
Catalog No.: PC-62378Not For Human Use, Lab Use Only.
InS3-54 is a small molecule STAT3 inhibitor that selectively targets the DNA-binding domain of STAT3, without affecting the activation and dimerization of STAT3.
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InS3-54 is a small molecule STAT3 inhibitor that selectively targets the DNA-binding domain of STAT3, without affecting the activation and dimerization of STAT3.
InS3-54 preferentially suppresses proliferation of cancer over non-cancer cells and inhibits migration and invasion of malignant cells.
InS3-54 selectively inhibits STAT3 binding to DNA without affecting the activation and dimerization of STAT3.
InS3-54 inhibits expression of STAT3 downstream target genes and STAT3 binding to chromatin in situ.
| M.Wt | 412.401 | |
| Formula | C24H16N2O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Huang W, et al. ACS Chem Biol. 2014 May 16;9(5):1188-96.
2. Huang W, et al. Oncogene. 2016 Feb 11;35(6):783-92.
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