Inarigivir ammonium (ORI-9020, SB-9000) is a dinucleotide that activates RIG-I and NOD2, induces interferon mediated antiviral immune responses. Inarigivir shows broad-spectrum antiviral activity against RNA viruses including HCV, norovirus, RSV and influenza, and also demonstrates activity HBV in vitro and in vivo. Inarigivir is a novel agonist of innate immunity. Inarigivir is the activite componet of Inarigivir soproxil (SB-9200).
Physicochemical Properties
M.Wt
604.53
Formula
C20H29N8O10PS
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
O-(((2R,3S,5R)-5-(6-amino-9H-purin-9-yl)-3-hydroxytetrahydrofuran-2-yl)methyl) O-((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-(hydroxymethyl)-4-methoxytetrahydrofuran-3-yl) S-hydrogen phosphorothioate, ammonia salt
References
1. Korolowicz KE, et al. PLoS One. 2016 Aug 23;11(8):e0161313.
2. Jones M, et al. J Med Virol. 2017 Sep;89(9):1620-1628.
3. Iyer RP, et al. Antimicrob Agents Chemother. 2004 Jun;48(6):2318-20.
