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Chemical Structure : Isoginkgetin
Catalog No.: PC-62507Not For Human Use, Lab Use Only.
Isoginkgetin (Iso-ginkgetin.
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Isoginkgetin (Iso-ginkgetin;IsoG) is a chemical inhibitor of Pre-mRNA splicing, does not target the SF3b subunit of the U2 snRNP, inhibits splicing both in vivo and in vitro at micromolar concentrations; appears to do so by preventing stable recruitment of the U4/U5/U6 tri-small nuclear ribonucleoprotein, resulting in accumulation of the prespliceosomal A complex; inhibits cell proliferation in a reversible fashion, inhibits promoter-proximal transcription elongation.
| M.Wt | 566.518 | |
| Formula | C32H22O10 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Boswell SA, et al. Nat Chem Biol. 2017 May;13(5):501-507.
2. O'Brien K, et al. J Biol Chem. 2008 Nov 28;283(48):33147-54.
3. Yoon SO, et al. Mol Cancer Ther. 2006 Nov;5(11):2666-75.
4. Liu G, et al. J Endocrinol. 2007 Sep;194(3):569-78.
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