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Chemical Structure : J-113863
CAS No.: 353791-85-2
Catalog No.: PC-20542Not For Human Use, Lab Use Only.
J-113863 is a potent, selective, non-peptide antagonist of CCR1 with IC50 of 0.9 and 5.8 nM for human and mouse CCR1 receptors, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $178 | In stock | |
| 25 mg | $298 | In stock | |
| 100 mg | $798 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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J-113863 is a potent, selective, non-peptide antagonist of CCR1 with IC50 of 0.9 and 5.8 nM for human and mouse CCR1 receptors, respectively.
J-113863 is inactive against CCR2, CCR4 and CCR5, as well as the LTB4 or TNF-α receptors.
J-113863 is also a potent antagonist of the human CCR3 (IC50=0.58 nM), but a weak antagonist of the mouse CCR3 (IC50=460 nM).
J-113863 improved paw inflammation and joint damage, and dramatically decreased cell infiltration into joints.
J-113863 did not inhibit IL-2 or DTH, but reduced plasma TNFα levels in LPS-treated mice.
J-113863 prevents the progression of in collagen-induced arthritis (CIA) model.
| M.Wt | 655.44 | |
| Formula | C30H37Cl2IN2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1-(1-cycloocten-1-ylmethyl)-4-(2,7-dichloroxanthen-9-ylcarboxamido)-1-ethylpiperidinium iodide |
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1. Amat M, et al. Br J Pharmacol. 2006 Nov;149(6):666-75.
2. Price PJ, et al. J Virol. 2014 Sep;88(18):10840-50.
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