J8-C8 | acyl-HSL synthase TofI inhibitor

Chemical Structure : J8-C8

J8-C8 (TofI inhibitor J8-C8)

Catalog No.: PC-62035Not For Human Use, Lab Use Only.

J8-C8 is a small-molecule inhibitor of bacterial N-acyl-homoserine lactone synthase (acyl-HSLs) TofI with IC50 of 35 uM for toxoflavin production.

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Biological Activity

J8-C8 is a small-molecule inhibitor of bacterial N-acyl-homoserine lactone synthase (acyl-HSLs) TofI with IC50 of 35 uM for toxoflavin production.
J8-C8 inhibits N-octanoyl-L-HSL (C8-HSL) synthesis in a dose-dependent manner.
J8-C8 is a new class of quorum sensing (QS)-inhibiting therapeutic agents.

Physicochemical Properties

M.Wt	237.343
Formula	C14H23NO2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(3-oxocyclohex-1-en-1-yl)octanamide

References

1. Chung J, et al. Proc Natl Acad Sci U S A. 2011 Jul 19;108(29):12089-94.

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J8-C8 (TofI inhibitor J8-C8)

Biological Activity

Physicochemical Properties

References

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