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Chemical Structure : JA2131
Catalog No.: PC-73117Not For Human Use, Lab Use Only.
JA2131 (NSC98003) is a potent, selective small molecule PARG inhibitor with IC50 of 0.4 uM.
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JA2131 (NSC98003) is a potent, selective small molecule PARG inhibitor with IC50 of 0.4 uM.
JA2131 binds to the adenine-binding pocket of hPARG.
JA2131 induces hyperPARylation of PARP1 in treated cells.
JA2131 sensitizes cells to radiation-induced DNA damage, suppresses replication fork progression and impedes cancer cell survival.
| M.Wt | 341.448 | |
| Formula | C13H19N5O2S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Houl JH, et al. Nat Commun. 2019 Dec 11;10(1):5654.
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