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JC124

Chemical Structure : JC124

CAS No.: 1638611-48-9

JC124 (JC-124)

Catalog No.: PC-20303Not For Human Use, Lab Use Only.

JC124 is a potent selective NLRP3 inflammasome inhibitor with IC50 of 3.25 uM for inhibition of IL-1β release by LPS/ATP-stimulated J774A.1 cells.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

JC124 is a potent selective NLRP3 inflammasome inhibitor with IC50 of 3.25 uM for inhibition of IL-1β release by LPS/ATP-stimulated J774A.1 cells.
JC-124 (50 mg/kg daily, i.p. injection) inhibits the NLRP3 signaling in TgCRND8 mice, decreases Aβ deposition, reduces β-cleavage of APP and Aβ production.
JC-124 reduces microgliosis but increases astrocytosis in TgCRND8 mice,.
JC-124 reduces oxidative stress in TgCRND8 mice after long-term treatment, improves the level of synaptic marker.

Physicochemical Properties

M.Wt 382.86
Formula C17H19ClN2O4S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

5-chloro-2-methoxy-N-(4-(N-methylsulfamoyl)phenethyl)benzamide

References

1. Yin J, et al. Mol Neurobiol. 2018 Mar;55(3):1977-1987.

2. Fulp J, et al. J Med Chem. 2018 Jun 28;61(12):5412-5423.

3. Marchetti C, et al. J Cardiovasc Pharmacol. 2015;66(1):1–8.

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