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Chemical Structure : JD-5037
CAS No.: 1392116-14-1
Catalog No.: PC-45531Not For Human Use, Lab Use Only.
JD-5037 is a potent, selective and peripherally restricted cannabinoid-1 (CB1) receptor blocker with IC50 of 2 nM, does not inhibit CB2 receptor (IC50>1000 nM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $78 | In stock | |
| 10 mg | $118 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | Get quote |
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JD-5037 is a potent, selective and peripherally restricted cannabinoid-1 (CB1) receptor blocker with IC50 of 2 nM, does not inhibit CB2 receptor (IC50>1000 nM).
JD-5037 was also characterized as an inverse agonist in forskolin-stimulated CHO cells over- expressing CB1-receptors by its ability to affect cAMP with EC50 of 46 nM.
JD-5037 showed little brain presence as indicated by tissue distribution and receptor occupancy studies.
JD-5037 (20 mg/kg PO) normalized triglyceride levels, liver mass and ALT as well a beneficial effect on glycemic control in model of diabetes.
| M.Wt | 572.506 | |
| Formula | C27H27Cl2N5O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 10 mM |
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| Chemical Name/SMILES |
Butanamide, 2-[[[(4S)-3-(4-chlorophenyl)-4,5-dihydro-4-phenyl-1H-pyrazol-1-yl][[(4-chlorophenyl)sulfonyl]amino]methylene]amino]-3-methyl-, (2S)- |
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1. Chorvat RJ, et al. Bioorg Med Chem Lett. 2012 Oct 1;22(19):6173-80.
2. Tam J, et al. Cell Metab. 2012 Aug 8;16(2):167-79.
3. Knani I, et al. Mol Metab. 2016 Oct 22;5(12):1187-1199.
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