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JG-98

Chemical Structure : JG-98

CAS No.: 1456551-16-8

JG-98 (JG98)

Catalog No.: PC-62492Not For Human Use, Lab Use Only.

JG-98 is an allosteric Hsp70 inhibitor, displays >3-fold more active, greater stability than MKT-077 against the breast cancer cell lines MDA-MB-231 and MCF-7 (EC50 of 0.4 uM and 0.7 uM, respectively).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

JG-98 is an allosteric Hsp70 inhibitor, displays >3-fold more active, greater stability than MKT-077 against the breast cancer cell lines MDA-MB-231 and MCF-7 (EC50 of 0.4 uM and 0.7 uM, respectively).
JG-98 strongly affects autophagic flux, increases p62 oligomerization and reduces p62 monomer.
JG-98 destabilizes FoxM1 and relieved suppression of downstream effectors, including p21 and p27.

Physicochemical Properties

M.Wt 534.532
Formula C24H21Cl2N3OS3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Thiazolium,2-[(Z)-[(5E)-5-(6-chloro-3-methyl-2(3H)-benzothiazolylidene)-3-ethyl-4-oxo-2-thiazolidinylidene]methyl]-3-(phenylmethyl)-,chloride (1:1)

References

1. Li X. et al. ACS Med Chem Lett. 2013 Nov 14;4(11).

2. Li X, et al. Mol Cancer Ther. 2015 Mar;14(3):642-8.

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