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Chemical Structure : JH-VIII-49
Catalog No.: PC-63464Not For Human Use, Lab Use Only.
JH-VIII-49 is a potent and selective inhibitor of CDK8 with IC50 of 16 nM, also inhibits CDK19 (IC50=8 nM).
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JH-VIII-49 is a potent and selective inhibitor of CDK8 with IC50 of 16 nM, also inhibits CDK19 (IC50=8 nM).
JH-VIII-49 displays excellent selectivity against a panel of 468 kinases at a concentration of 10 uM, only 4 has >90% inhibition.
JH-VIII-49 induces a dose-dependent inhibition of S727-STAT1 phosphorylation in HepG2 cells (at 5 uM).
| M.Wt | 428.664 | |
| Formula | C30H40N2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. John M. Hatcher, et al. ACS Med. Chem. Lett. DOI: 10.1021/acsmedchemlett.8b00011
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