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Chemical Structure : JHU37152
CAS No.: 2369979-67-7
Catalog No.: PC-73158Not For Human Use, Lab Use Only.
JHU37152 is a high affinity and highly potent activator (agonist) of hM3Dq and hM4Di DREADDs with Ki 1.8 nM and 8.7 nM for hM3Dq and hM4Di in vitro.
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|---|---|---|---|
| 25 mg | $258 | In stock | |
| 50 mg | $428 | In stock | |
| 100 mg | $728 | In stock | |
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JHU37152 is a high affinity, highly potent, BBB penetrant activator (agonist) of hM3Dq and hM4Di DREADDs with Ki 1.8 nM and 8.7 nM for hM3Dq and hM4Di in vitro.
JHU37152 selectively displaces [3H]clozapine from DREADDs in vivo, but not from other clozapine binding sites.
JHU37152 inhibits locomotor activity in mice expressing hM3Dq and hM4Di in D1-expressing neurons.
Designer receptors exclusively activated by designer drugs (DREADD) technology is a powerful chemogenetic approach used for neuromodulation in uninstrumented research animals.
| M.Wt | 358.85 | |
| Formula | C19H20ClFN4 | |
| Appearance | Solid | |
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1. Jordi Bonaventura, et al. Nat Commun. 2019 Oct 11;10(1):4627.
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