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Chemical Structure : JJKK-048
CAS No.: 1515855-97-6
Catalog No.: PC-60701Not For Human Use, Lab Use Only.
JJKK-048 (JJKK048) is a potent, highly selective monoacylglycerol lipase (MAGL) with IC50 of <0.4 nM against human and rodent MAGL.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $188 | In stock | |
| 25 mg | $298 | In stock | |
| 100 mg | $598 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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JJKK-048 (JJKK048) is a potent, highly selective monoacylglycerol lipase (MAGL) with IC50 of <0.4 nM against human and rodent MAGL。
JJKK-048 exhibits extremely high potency in inhibiting MAGL in the brain and peripheral tissues and maintains good selectivity over other serine hydrolases。
JJKK-048 remarkably increases mouse brain 2-AG levels without affecting AEA levels, induces antinociception and dose-dependent hypomotility and hypothermia but no catalepsy in vivo.
| M.Wt | 434.44 | |
| Formula | C23H22N4O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
{4-[bis-(benzo[d][1,3]dioxol-5-yl)methyl]-piperidin-1-yl}(1H-1,2,4-triazol-1-yl)methanone |
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1. Aaltonen N, et al. Chem Biol. 2013 Mar 21;20(3):379-90.
2. Aaltonen N, et al. J Pharmacol Exp Ther. 2016 Oct;359(1):62-72.
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