JK-4b

Chemical Structure : JK-4b

Catalog No.: PC-28798Not For Human Use, Lab Use Only.

JK-4b is a highly potent non-nucleoside reverse transcriptase inhibitor (NNRTI) with EC50 of 1 nM against WT HIV-1.

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Biological Activity

JK-4b is a highly potent non-nucleoside reverse transcriptase inhibitor (NNRTI) with EC50 of 1 nM against WT HIV-1.

M.Wt	416.49
Formula	C26H20N6
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4'-((2-((4-cyanophenyl)amino)pyrimidin-4-yl)amino)-3',5'-dimethyl-[1,1'-biphenyl]-4-carbonitrile

1. Jin X, et al. Acta Pharm Sin B. 2023 Mar;13(3):1192-1203.

2. Zhang YJ, et al. J Med Chem. 2026 Sep 24;69(18):21522-21537.