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JLT048

Chemical Structure : JLT048

CAS No.: 664357-58-8

JLT048 (JLT-048)

Catalog No.: PC-20287Not For Human Use, Lab Use Only.

JLT048 is a small molecule inhibitor of tyrosyl-DNA-phosphodiesterases 1 and 2 (TDP1 and TDP2) with IC50 of 7.7 and 32 uM, respectively.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

JLT048 is a small molecule inhibitor of tyrosyl-DNA-phosphodiesterases 1 and 2 (TDP1 and TDP2) with IC50 of 7.7 and 32 uM, respectively.

Physicochemical Properties

M.Wt 406.37
Formula C22H15FN2O5
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

4-[5-[[1-[(2-Fluorophenyl)methyl]-2,5-dioxo-4-imidazolidinylidene]methyl]-2-furanyl]benzoic acid

References

1. Marchand C, et al. Mol Cancer Ther. 2014 Aug;13(8):2116-26.

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