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Chemical Structure : JMS-17-2
CAS No.: 1380392-05-1
Catalog No.: PC-35323Not For Human Use, Lab Use Only.
JMS-17-2 is a potent and selective antagonist of CX3CR1 with IC50 of 0.32 nM, displays significant selectivity for CX3CR1 over other chemokine receptors such CXCR2, CXCR1, and CXCR4 (IC50>1 uM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $88 | In stock | |
| 10 mg | $138 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | $368 | In stock | |
| 100 mg | Get quote |
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JMS-17-2 is a potent and selective antagonist of CX3CR1 with IC50 of 0.32 nM, displays significant selectivity for CX3CR1 over other chemokine receptors such CXCR2, CXCR1, and CXCR4 (IC50>1 uM).
JMS-17-2 effectively blocks FKN-induced ERK phosphorylation, also significantly reduces the migration of breast cancer cells in vitro.
JMS-17-2 impairs metastatic seeding and colonization of breast cancer cells, shows long-term anti-tumor effects in vivo.
| M.Wt | 419.953 | |
| Formula | C25H26ClN3O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
5-[3-[4-(4-Chlorophenyl)-1-piperidinyl]propyl]pyrrolo[1,2-a]quinoxalin-4(5H)-one |
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1. Shen F, et al. Mol Cancer Res. 2016 Jun;14(6):518-27.
2. Stout MC, et al. Biochem Biophys Res Commun. 2018 Jan 15;495(3):2264-2269.
3. Naya A, et al. J Med Chem. 2001 Apr 26;44(9):1429-35.
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