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Chemical Structure : JMX0286
Catalog No.: PC-49140Not For Human Use, Lab Use Only.
JMX0286 is a potent, specific and allosteric inhibitor against SARS-CoV-2 3CLpro with IC50 of 4.8 uM in FRET based screening assays, shows strong inhibition of SARS-CoV-2 virus with EC50 of 2.25 uM in A549-hACE2 cells.
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JMX0286 is a potent, specific and allosteric inhibitor against SARS-CoV-2 3CLpro with IC50 of 4.8 uM in FRET based screening assays, shows strong inhibition of SARS-CoV-2 virus with EC50 of 2.25 uM in A549-hACE2 cells.
JMX0286 shows little to no inhibitor activity against cathepsin B (CatB) and L (CatL) enzymes with IC50 of >100 uM.
JMX0286 effectively inhibits the cleavage of the TriPro substrate protein in a dose dependent manner.
JMX0286 directly and specifically to an allosteric pocket of the SARS-CoV-2 3CL protease with KD value of 9.8 uM in SPR assays.
| M.Wt | 463.696 | |
| Formula | C17H17Cl3N4O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Samrat SK, et al. Antiviral Res. 2022 Jul 11;205:105381.
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