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Chemical Structure : JNJ-10198409
Catalog No.: PC-62328Not For Human Use, Lab Use Only.
JNJ-10198409 is a highly potent, selective PDGFRβ inhibitor with IC50 of 4.2 nM.
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JNJ-10198409 is a highly potent, selective PDGFRβ inhibitor with IC50 of 4.2 nM; displays >10-fold selectivity over PDGFRα (IC50=45 nM), and 5-fold over c-ABL (IC50=22 nM), >500-fold over a panel of kinases; also has modest activity against have modest activity against c-Src/Lck/Fyn (IC50=185/100/378 nM); shows potent antiproliferative activity for human tumor cell lines (IC50=33 nM); regulates Oct4 and Nanog expression, cell shape, and mesenchymal stem cell potency.
| M.Wt | 325.343 | |
| Formula | C18H16FN3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Ho CY, et al. J Med Chem. 2005 Dec 29;48(26):8163-73.
2. D'Andrea MR, et al. Mol Cancer Ther. 2005 Aug;4(8):1198-204.
3. Ball SG, et al. Stem Cells. 2012 Mar;30(3):548-60.
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