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JNJ-26070109

Chemical Structure : JNJ-26070109

CAS No.: 844645-08-5

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JNJ-26070109 (JNJ 26070109, JNJ26070109)

Catalog No.: PC-70196Not For Human Use, Lab Use Only.

JNJ-26070109 is a novel, potent, selective orally active CCK-2 receptor antagonist with pKi of 8.49 for hCCK2.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    JNJ-26070109 is a novel, potent, selective orally active CCK-2 receptor antagonist with pKi of 8.49 for hCCK2.
    JNJ-26070109 displays >1200-fold selectivity over hCCK1 receptor.
    JNJ-26070109 has oral EC50 of 1.5 and 0.26 uM in conscious rat and dog chronic gastric fistula models of pentagastrin-stimulated acid secretion, respectively.
    JNJ-26070109 inhibits gastric acid secretion and prevents omeprazole-induced acid rebound in the rats.

    Physicochemical Properties

    M.Wt 547.37
    Formula C23H17BrF2N4O3S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (R)-4-Bromo-N-[1-(2,4-difluorophenyl)ethyl]-2-[[(quinoxalin-5-yl)sulfonyl]amino]benzamide

    References

    1. Morton MF, et al. J Pharmacol Exp Ther. 2011 Jul;338(1):328-36.

    2. Barrett TD, et al. Br J Pharmacol. 2012 Jul;166(5):1684-93.

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