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Chemical Structure : JNJ-26993135
Catalog No.: PC-63409Not For Human Use, Lab Use Only.
JNJ-26993135 is a potent, selective leukotriene A4 hydrolase (LTA4H) inhibitor, inhibits both the epoxide hydrolase and aminopeptidase activities of recombinant human LTA4H with IC50 of 10 nM.
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JNJ-26993135 is a potent, selective leukotriene A4 hydrolase (LTA4H) inhibitor, inhibits both the epoxide hydrolase and aminopeptidase activities of recombinant human LTA4H with IC50 of 10 nM.
JNJ-26993135 has no significant effects on LTC4, lipoxin A4, or PGE2 production.
JNJ-26993135 dose-dependently inhibits ex vivo LTB(4) production in blood (IC50=339 nM), in parallel with dose-dependent inhibition of neutrophil influx (ED50, 1-3 mg/kg) and ear edema in murine model of arachidonic acid-induced ear inflammation.
JNJ-26993135 selectively inhibited LTB(4) production, without affecting cysteinyl leukotriene production.
| M.Wt | 368.451 | |
| Formula | C20H20N2O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Rao NL, et al. J Pharmacol Exp Ther. 2007 Jun;321(3):1154-60.
2. Whittle BJ, et al. Br J Pharmacol. 2008 Mar;153(5):983-91.
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