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Chemical Structure : JNJ-38877605
CAS No.: 943540-75-8
Catalog No.: PC-45841Not For Human Use, Lab Use Only.
JNJ-38877605 is a potent, selective, ATP-competitive inhibitor of catalytic activity c-Met with IC50 of 4 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $98 | In stock | |
| 25 mg | $158 | In stock | |
| 50 mg | $258 | In stock | |
| 100 mg | Get quote |
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JNJ-38877605 is a potent, selective, ATP-competitive inhibitor of catalytic activity c-Met with IC50 of 4 nM.
JNJ-38877605 exhibits >600-fold selectivity (cFMS IC50=2.6 uM, the next potently inhibited kinase) against a panel of 250 diverse tyrosine and serine-threonine kinases.
JNJ-38877605 inhibits Met phosphorylation associated with dose-dependent tumor growth inhibition in tumor xenograft models; orally bioavailable.
| M.Wt | 377.3502 | |
| Formula | C19H13F2N7 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 30 mg/mL |
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| Chemical Name/SMILES |
Quinoline, 6-[difluoro[6-(1-methyl-1H-pyrazol-4-yl)-1,2,4-triazolo[4,3-b]pyridazin-3-yl]methyl]- |
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1. Peter King, et al. DOI: 10.1158/1538-7445.AM10-3628 Published April 2010
2. Lolkema MP, et al. Clin Cancer Res. 2015 May 15;21(10):2297-2304.
3. Galimi F, et al. Clin Cancer Res. 2011 May 15;17(10):3146-56.
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