Chemical Structure : JNJ-38877618
CAS No.: 943540-74-7
Catalog No.: PC-63402Not For Human Use, Lab Use Only.
JNJ-38877618 (OMO-1) is a novel potent, highly selective, orally bioavailable c-Met tyrosine kinase inhibitor with Kd of 1.2, 2.1 and 21 nM for WT, M1250T and Y1235D mutants MET, respectively.
Packing | Price | Stock | Quantity |
---|---|---|---|
25 mg (3-4 weeks) | $488 | In stock | |
100 mg (3-4 weeks) | $988 | In stock | |
250 mg (3-4 weeks) | $1680 | In stock | |
1 g | Get quote |
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JNJ-38877618 (OMO-1) is a novel potent, highly selective, orally bioavailable c-Met tyrosine kinase inhibitor with Kd of 1.2, 2.1 and 21 nM for WT, M1250T and Y1235D mutants MET, respectively; potently inhibits MET receptor phosphorylation and downstream pathway modulation in the nanomolar range and induces anti-proliferative and anti-migratory activity in models with MET gene amplification, mutant or ligand-mediated pathway activation; completely suppresses tumour growth SNU5 MET amplified gastric, U87-MG HGF autocrine glioblastoma and Hs746T MET exon 14 skipping mutant gastric cancer models.
Solid Tumors
Phase 1 Clinical
M.Wt | 374.355 | |
Formula | C20H12F2N6 | |
Appearance | Solid | |
Storage |
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Solubility |
10 mM in DMSO |
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Chemical Name/SMILES |
6-(difluoro(6-(pyridin-4-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methyl)quinoline |
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