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JNJ-38877618

Chemical Structure : JNJ-38877618

CAS No.: 943540-74-7

JNJ-38877618 (OMO1;JNJ38877618;OMO-1)

Catalog No.: PC-63402Not For Human Use, Lab Use Only.

JNJ-38877618 (OMO-1) is a novel potent, highly selective, orally bioavailable c-Met tyrosine kinase inhibitor with Kd of 1.2, 2.1 and 21 nM for WT, M1250T and Y1235D mutants MET, respectively.

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25 mg (3-4 weeks) $488 In stock
100 mg (3-4 weeks) $988 In stock
250 mg (3-4 weeks) $1680 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

JNJ-38877618 (OMO-1) is a novel potent, highly selective, orally bioavailable c-Met tyrosine kinase inhibitor with Kd of 1.2, 2.1 and 21 nM for WT, M1250T and Y1235D mutants MET, respectively; potently inhibits MET receptor phosphorylation and downstream pathway modulation in the nanomolar range and induces anti-proliferative and anti-migratory activity in models with MET gene amplification, mutant or ligand-mediated pathway activation; completely suppresses tumour growth SNU5 MET amplified gastric, U87-MG HGF autocrine glioblastoma and Hs746T MET exon 14 skipping mutant gastric cancer models.

Solid Tumors

Phase 1 Clinical

Physicochemical Properties

M.Wt 374.355
Formula C20H12F2N6
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

6-(difluoro(6-(pyridin-4-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methyl)quinoline

References

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