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Chemical Structure : JNJ-40411813
CAS No.: 1127498-03-6
Catalog No.: PC-61513Not For Human Use, Lab Use Only.
JNJ-40411813 is a novel potent positive allosteric modulator of mGlu2 with EC50 of 147 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $348 | In stock | |
| 25 mg | $798 | In stock | |
| 100 mg | Get quote | ||
| 250 mg | Get quote | ||
| 1 g | Get quote |
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JNJ-40411813 is a novel potent positive allosteric modulator of mGlu2 with EC50 of 147 nM.
JNJ-40411813 displays >30-fold selectivity over mGlu1 and mGlu3-8, 10-fold over 5-HT2A.
JNJ-40411813 displays an optimal interplay between potency, selectivity, favorable ADMET/PK and cardiovascular safety profile, and central EEG activity; has been investigated in the clinic for schizophrenia and anxious depression disorders.
| M.Wt | 344.883 | |
| Formula | C20H25ClN2O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone |
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1. Cid JM, et al. J Med Chem. 2014 Aug 14;57(15):6495-512.
2. Ahnaou A, et al. Neuropharmacology. 2016 Apr;103:290-305.
3. Lavreysen H, et al. Pharmacol Res Perspect. 2015 Mar;3(2):e00097.
4. Kent JM, et al. Prog Neuropsychopharmacol Biol Psychiatry. 2016 Jun 3;67:66-73.
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