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Chemical Structure : JNJ-42041935
CAS No.: 1193383-09-3
Catalog No.: PC-43241Not For Human Use, Lab Use Only.
JNJ-42041935 is a potent, selective, 2-OG-competitive, reversible inhibitor of HIF-PHD with pKi of 7.91, 7.29 and 7.65 for PHD1, PHD2 and PHD3, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $108 | In stock | |
| 25 mg | $328 | In stock | |
| 100 mg | $868 | In stock | |
| 500 mg | Get quote |
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JNJ-42041935 is a potent, selective, 2-OG-competitive, reversible inhibitor of HIF-PHD with pKi of 7.91, 7.29 and 7.65 for PHD1, PHD2 and PHD3, respectively; shows highly selectivity for PHD relative to FIH (pIC50=4.0); JNJ-42041935 is approximately equipotent in the HIF-1α accumulation and erythropoietin secretion assays in Hep3B cells as DMOG and 3,4-EDHB; reverses inflammation-induced anemia at dose of 100 μmol/kg, whereas erythropoietin has no effect.
| M.Wt | 346.6493 | |
| Formula | C12H6ClF3N4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 36 mg/mL |
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| Chemical Name/SMILES |
1H-Pyrazole-4-carboxylic acid, 1-[6-chloro-5-(trifluoromethoxy)-1H-benzimidazol-2-yl]- |
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1. Barrett TD, et al. Mol Pharmacol. 2011 Jun;79(6):910-20.
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