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JNJ-42905343

Chemical Structure : JNJ-42905343

CAS No.: 1238689-36-5

JNJ-42905343 (JNJ 42905343;JNJ42905343)

Catalog No.: PC-61213Not For Human Use, Lab Use Only.

JNJ-42905343 is a potent, selective, orally active prolyl hydroxylase (PHD) inhibitor with pKi of 8.07, 7.48 and 7.27 for PHD1, PHD2 and PHD3 respectively.

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    Biological Activity

    JNJ-42905343 is a potent, selective, orally active prolyl hydroxylase (PHD) inhibitor with pKi of 8.07, 7.48 and 7.27 for PHD1, PHD2 and PHD3 respectively; stabilizes HIF1-α in a concentration-dependent fashion in HeLa cells (EC50=19.7 uM) and stimulates the release of EPO from Hep3B cells (EC50=20.3 uM); increases blood haemoglobin, mean corpuscular haemoglobin (MCH) and mean corpuscular volume (MCV), corrects functional iron deficiency and inflammation-induced anaemia in rats.

    Physicochemical Properties

    M.Wt 394.362
    Formula C20H15FN4O4
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    1-(6-(2,6-dimethylphenoxy)-7-fluoro-4-oxo-3,4-dihydroquinazolin-2-yl)-1H-pyrazole-4-carboxylic acid

    References

    1. Barrett TD, et al. Br J Pharmacol. 2015 Aug;172(16):4078-88.

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