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Chemical Structure : JNJ-46778212
CAS No.: 1363281-27-9
Catalog No.: PC-60696Not For Human Use, Lab Use Only.
JNJ-46778212 (VU0409551) is a potent, selective, CNS penetrant and orally bioavailable mGlu5 positive allosteric modulator that potentiates human mGlu5 with EC50 of 260 nM
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $248 | In stock | |
| 100 mg | $658 | In stock | |
| 500 mg | Get quote | ||
| 1 g | Get quote |
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JNJ-46778212 (VU0409551) is a potent, selective, CNS penetrant and orally bioavailable mGlu5 positive allosteric modulator that potentiates human mGlu5 with EC50 of 260 nM.
JNJ-46778212 potentiates DHPG-induced long-term depression and induces calcium mobilization and ERK phosphorylation, does not potentiate mGlu5 modulation of NMDA receptor currents nor NMDA receptor-dependent long-term potentiation.
JNJ-46778212 demonstrates in vivo efficacy in multiple preclinical models o schizophrenia, coupled with good DMPK profile and acceptable therapeutic window.
| M.Wt | 352.365 | |
| Formula | C20H17FN2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
100 mM in DMSO (35.2 mg/mL) |
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| Chemical Name/SMILES |
(4-fluorophenyl)(2-(phenoxymethyl)-6,7-dihydrooxazolo[5,4-c]pyridin-5(4H)-yl)methanone |
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1. Conde-Ceide S, et al. ACS Med Chem Lett. 2015 May 20;6(6):716-20.
2. Zhou Y, et al. Bioorg Med Chem Lett. 2015 Sep 1;25(17):3515-9.
3. Conde-Ceide S, et al. Bioorg Med Chem Lett. 2016 Jan 15;26(2):429-434.
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