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Chemical Structure : JNJ-61803534
Catalog No.: PC-72400Not For Human Use, Lab Use Only.
JNJ-61803534 (JNJ 61803534) is a novel, selective and potent RORγt inverse agonist, inhibits RORγt-driven transcription with IC50 of 9.6 nM in 1-hybrid reporter assays.
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JNJ-61803534 (JNJ 61803534) is a novel, selective and potent RORγt inverse agonist, inhibits RORγt-driven transcription with IC50 of 9.6 nM in 1-hybrid reporter assays.
JNJ-61803534 demonstrated high selectivity for RORγt over RORα and RORβ (IC50>2 uM), as well as against 18 human nuclear receptors and a panel of 52 receptors, ion channels and transporters, 28 GPCRs.
JNJ-61803534 dose-dependently suppressed production of IL-17A, IL-17F and IL-22 with IC50 values of 19nM, 22 nM and 27 nM, respectively, in human CD4+ T cells under Th17 differentiation, does not impair human nTreg suppressive function.
JNJ-61803534 specifically blocked RORγt-dependent pathways in cellular assays and significantly reduced inflammation in preclinical models.
| M.Wt | 622.404 | |
| Formula | C23H23Cl2F6N3O4S | |
| Appearance | Solid | |
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1. Xiaohua Xue, et al. Sci Rep. 2021 May 26;11(1):11066.
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