Chemical Structure : JNJ 10329670
CAS No.:
400797-24-2
JNJ 10329670
(JNJ-10329670, JNJ10329670)
Catalog No.: PC-27080Not For Human Use, Lab Use Only.
JNJ 10329670 (JNJ10329670) is a potent and selective, noncovalent human cathepsin S (CatS) inhibitor with Ki of 30 nM, is much less active against the mouse, dog, monkey, and bovine CatS.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
JNJ 10329670 (JNJ10329670) is a potent and selective, noncovalent human cathepsin S (CatS) inhibitor with Ki of 30 nM, is much less active against the mouse, dog, monkey, and bovine CatS.
JNJ 10329670 is inactive against other proteases, including the closely related cathepsins L, F, and K.
JNJ 10329670 induces accumulation of the p10 fragment of the invariant chain in human B cell lines and primary human dendritic cells with IC50 of approximately 1 uM.
JNJ 10329670 blocks the proteolysis of the invariant chain in vivo by using immunocompromised mice injected with human peripheral blood mononuclear cells (PBMCs).
JNJ 10329670 blocks the presentation of tetanus toxoid and giant ragweed by human PBMCs.
Physicochemical Properties
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M.Wt
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651.15
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Formula
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C30H34ClF3N6O3S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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5-chloro-1-methyl-3-(1-(3-(5-(methylsulfonyl)-3-(4-(trifluoromethyl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-1-yl)propyl)piperidin-4-yl)-1,3-dihydro-2H-benzo[d]imidazol-2-one
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References
1. Thurmond RL, et al. J Pharmacol Exp Ther. 2004 Jan;308(1):268-76.
2. Gustin DJ, et al. Bioorg Med Chem Lett. 2005 Mar 15;15(6):1687-91.
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