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JNJ4796

Chemical Structure JNJ4796

CAS No.: 2241664-16-2

JNJ4796 (JNJ-4796;JNJ 4796)

Catalog No.: PC-36123Not For Human Use, Lab Use Only.

JNJ4796 (JNJ 4796, JNJ-4796) is an orally active small-molecule fusion inhibitor of influenza virus hemagglutinin (HA) with EC50 of 33 nM (H1N1 neutralization).

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

JNJ4796 (JNJ 4796, JNJ-4796) is an orally active small-molecule fusion inhibitor of influenza virus hemagglutinin (HA) with EC50 of 33 nM (H1N1 neutralization); mimics the binding and functionality of the broadly neutralizing antibody CR6261; targets the conserved HA stem region, acts as a fusion inhibitor by inhibiting conformational changes that lead to the postfusion HA structure, and neutralizes a broad spectrum of human pandemic, seasonal, and emerging group 1 influenza A viruses; specificly neutralizes influenza A group 1 viruses by inhibiting HA-mediated fusion in vitro, protects mice against lethal and sublethal influenza challenge after oral administration.

Physicochemical Properties

M.Wt 537.584
Formula C28H27N9O3
CAS No. 2241664-16-2
Storage
Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 3 Month
Shipping
Solubility

Chemical Name

(R)-N-(2-(2-(4-((2-methyl-2H-tetrazol-5-yl)(phenyl)methyl)piperazine-1-carbonyl)pyridin-4-yl)benzo[d]oxazol-5-yl)acetamide

Clinical Information

References

1. van Dongen MJP, et al. Science. 2019 Mar 8;363(6431). pii: eaar6221. doi: 10.1126/science.aar6221.

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