Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : JPH203
CAS No.: 1037592-40-7
Catalog No.: PC-42276Not For Human Use, Lab Use Only.
Nanvuranlat (JPH203, KYT-0353) is a potent, selective L-type amino acid transporter 1 (LAT1, SLC7A5) inhibitor with IC50 of 60 nM (leucine uptake inhibition), but not LAT2.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $98 | In stock | |
| 10 mg | $168 | In stock | |
| 25 mg | $298 | In stock | |
| 100 mg | $698 | In stock | |
| 250 mg | Get quote | ||
| 1 g | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Nanvuranlat (JPH203, KYT-0353) is a potent, selective L-type amino acid transporter 1 (LAT1, SLC7A5) inhibitor with IC50 of 60 nM (leucine uptake inhibition), but not LAT2.
JPH203 inhibits cell growth in HT-29 cells with IC50 of 4.1 uM, also inhibits (14)C-leucine uptake in mouse renal proximal tubule cells expressing LAT1 and inhibits cell growth with IC50 of 0.14 and 16.4 uM, respectively.
JPH203 significant inhibits HT-29 tumor growth in vivo.
| M.Wt | 472.32066 | |
| Formula | C23H19Cl2N3O4 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
L-Tyrosine, O-[(5-amino-2-phenyl-7-benzoxazolyl)methyl]-3,5-dichloro- |
|
1. Oda K, et al. Cancer Sci. 2010 Jan;101(1):173-9.
2. Yun DW, et al. J Pharmacol Sci. 2014;124(2):208-17.
3. Wempe MF, et al. Drug Metab Pharmacokinet. 2012;27(1):155-61.
4. Rosilio C, et al. Leukemia. 2015 Jun;29(6):1253-66.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
