Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : JSH-23
CAS No.: 749886-87-1
Catalog No.: PC-21743Not For Human Use, Lab Use Only.
JSH-23 is a small molecule NF-κB inhibitor, inhibits NF-κB transcriptional activity with IC50 of 7.1 uM in LPS-stimulated macrophages RAW 264.7.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $288 | In stock | |
| 100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
JSH-23 is a small molecule NF-κB inhibitor, inhibits NF-κB transcriptional activity with IC50 of 7.1 uM in LPS-stimulated macrophages RAW 264.7.
JSH-23 inhibits nuclear translocation of NF-κB p65 without affecting IκBα degradation.
JSH-23 (<100 uM) does not show significant cytotoxic effects on the RAW 264.7 cells.
JSH-23 (1 mg/kg, 3 mg/kg; oral daily for 2 weeks) significantly reverses the nerve conduction and nerve blood flow deficits seen in diabetic rats.
| M.Wt | 240.35 | |
| Formula | C16H20N2 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
4-Methyl-N1-(3-phenylpropyl)benzene-1,2-diamine |
|
1. Shin HM, et al. FEBS Lett. 2004 Jul 30;571(1-3):50-4.
2. Kumar A, et al. Diabetes Obes Metab. 2011 Aug;13(8):750-8.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
