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Chemical Structure : JT001
Catalog No.: PC-20912Not For Human Use, Lab Use Only.
JT001 (JT-001) is a potent, highly specific NLRP3 inhibitor, inhibits NLRP3 inflammasome assembly.
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JT001 (JT-001) is a potent, highly specific NLRP3 inhibitor, inhibits NLRP3 inflammasome assembly.
JT001 potently and selectively inhibited NLRP3 inflammasome assembly, resulting in the inhibition of cytokine release and the prevention of pyroptosis, a form of inflammatory cell death triggered by active caspase-1, in cell-based assays.
Orally administered JT001 was effective in reducing hepatic inflammation in three different murine models, including the Nlrp3A350V/+CreT model of Muckle-Wells syndrome (MWS), a diet-induced obesity NASH model, and a choline-deficient diet-induced NASH model.
| M.Wt | 246.24 | |
| Formula | C7H10N4O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Povero D, et al. J Pharmacol Exp Ther. 2023 Aug;386(2):242-258.
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