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Chemical Structure : JT010
CAS No.: 917562-33-5
Catalog No.: PC-49684Not For Human Use, Lab Use Only.
JT010 (JT-010) is a potent, site-selective and covalent TRPA1 agonist, opens the TRPA1 channel by covalently and site-selectively binding to Cys621 with EC50 of 0.65 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $248 | In stock | |
| 25 mg | $448 | In stock | |
| 50 mg | $728 | In stock | |
| 100 mg | $1280 | In stock | |
| 1 g | Get quote |
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JT010 (JT-010) is a potent, site-selective and covalent TRPA1 agonist, opens the TRPA1 channel by covalently and site-selectively binding to Cys621 with EC50 of 0.65 nM.
JT010 is highly selective for TRPA1 over TRPV1, TRPV3, TRPV4, TRPM2, TRPM8, and TRPC5 (EC50 values >1 uM).
JT010 (10 nM) failed to stimulate calcium influx in the C621S mutant cells but induced calcium influx in the wild type cells.
JT010 could induce TRPA1-specific pain model. increased the intracellular calcium concentration and extracellular signal-regulated kinase 1/2 phosphorylation, and up-regulated alkaline phosphatase mRNA in human dental pulp cells.
Topical treatment of TRPA1 specific agonist JT010 increased UVB-induced skin pigmentation in guinea pigs.
| M.Wt | 354.85 | |
| Formula | C16H19ClN2O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-chloro-N-(4-(4-methoxyphenyl)thiazol-2-yl)-N-(3-methoxypropyl)acetamide |
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1. Takaya J, et al. J Am Chem Soc. 2015 Dec 23;137(50):15859-64.
2. Heber S, et al. J Neurosci. 2019 May 15;39(20):3845-3855.
3. Tazawa K, et al. Am J Pathol. 2020 Dec;190(12):2417-2426.
4. Wu W, et al. Exp Dermatol. 2022 Oct 27. doi: 10.1111/exd.14693.
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