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Chemical Structure : JTP-0157602
Catalog No.: PC-72632Not For Human Use, Lab Use Only.
JTP-0157602 (JTP0157602) is a novel non-catalytic site integrase inhibitor of HIV-1 integrase (IN), inhibits the interaction between LEDGF IBD and IN with IC50 of 4.2 nM.
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JTP-0157602 (JTP0157602) is a novel non-catalytic site integrase inhibitor of HIV-1 integrase (IN), inhibits the interaction between LEDGF IBD and IN with IC50 of 4.2 nM.
JTP-0157602 exhibits potent antiviral activity against HIV-1 with EC90 of 138 nM.
JTP-0157602 retained potent antiviral activity (EC50=1-6 nM) against a broad panel of recombinant viruses with INSTI-related resistant mutations, including multiple substitutions that emerged in clinical studies of INSTIs (IN strand transfer inhibitors (INSTIs).
JTP-0157602 inhibited HIV-1 replication mainly during the late-phase of the replication cycle.
JTP-0157602 binds to the LEDGF/p75 binding pocket of HIV-1 integrase (IN).
| M.Wt | 687.857 | |
| Formula | C39H50FN5O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Yoshitsugu Ohata, et al. J Virol. 2022 Jan 19;JVI0184321.
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