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Chemical Structure : JTP-109192
Catalog No.: PC-20442Not For Human Use, Lab Use Only.
JTP-109192 (JTP109192) is a potent GPR119 agonist with EC50 of 3.6. 4.5 and 5.2 nM for human, rat and mouse GPR119 respectively (increased intracellular cAMP levels).
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JTP-109192 (JTP109192) is a potent GPR119 agonist with EC50 of 3.6. 4.5 and 5.2 nM for human, rat and mouse GPR119 respectively (increased intracellular cAMP levels).
JTP-109192 (0.1-10 uM) significantly increased GLP-1 secretion in GLUTag cells, at 10 uM, 5.6 -fold increase by JTP-109192 was observed as compared with DMSO alone.
JTP-109192 enhanced glucose stimulated insulin secretion (GSIS) in the INS1E cells.
A single administration of JTP-109192 (10 mg/kg) enhanced GSIS at high blood glucose levels in Sprague-Dawley (SD) rats.
A repeated administrations (10 mg/kg) in ZF rats improved glucose metabolism without lack of drug efficacy (tachyphylaxis) and increased glucose infusion rates due to improvement of insulin sensitivity.
| M.Wt | 401.59 | |
| Formula | C25H39NO3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Hironobu Tadaki, et al. Clin Exp Pharmacol Physiol. 2019 Oct;46(10):910-919.
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